※ TSSK family introduction

    TSSK (testis-specific serine kinase) belongs to CAMK group. Six members have been identified in this family in human genome.However, only five possess kinase catalytic domain including TSSK1, TSSK2, TSSK3, TSSK4 and TSSK6. TSSKs contain a kinase domain and a variable short C-terminal extension. All members contain a conserved activation loop threonine phosphorylation site. Two members TSSK2 and TSSK3 can undergo autophosphorylation. TSSK1 and TSSK2 are formed by tandem duplication and a dual knockout is infertile as a heterozygote. TSSK3 is expressed only in interstitial Leydig cells, which contrasts with the expression of TSSK1 and TSSK2 in late spermatids and sperm. TSSK4 can bind to CREB by Y2H and can phosphorylate and activate CREB in human and mouse cells (1).

Reference
1. Wikinome Annotation:    Kinase Family TSSK

  Reviewed (0)  or Unreviewed (5) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sus-0164	ENSSSCG00000010112.2	F1RK80	TSSK1B
2		iEKPD-Sus-0165	ENSSSCG00000010113.2	F1RK79	TSSK2
3		iEKPD-Sus-0336	ENSSSCG00000023968.2	I3L7T3	TSSK3
4		iEKPD-Sus-0355	ENSSSCG00000025470.2	I3LBD3	TSSK4
5		iEKPD-Sus-0240	ENSSSCG00000013937.3	F1S6Q0	TSSK6