※ Trbl family introduction

    Trbl belongs to CAMK group. Three genes encoding trbl have been identified in mammals, and the related orthologus also been found in vertebrates and invertebrates. The Trbl kinases share a conserved central kinase catalytic domain flanked by not unclosely related N-terminal and C-terminal sequences. However, the kinase domains lack the key active site lysine and might be an inactive kinase. Studies show that Trbl kinases are key molecule function on controlling Mitogen-activated protein kinase cascades. For instance, human trbl-1 overexpression can modulate the activation of Ras/MEK-1/ERK pathway, and some MAPKK interacts with Trbls which results enhance of kinase activation (1).

Reference
1. Kiss-Toth, E., Bagstaff, S.M., Sung, H.Y., Jozsa, V., Dempsey, C., Caunt, J.C., Oxley, K.M., Wyllie, D.H., Polgar, T., Harte, M. et al. (2004) Human tribbles, a protein family controlling mitogen-activated protein kinase cascades. J Biol Chem, 279, 42703-42708. PMID: 15299019

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Anc-0253	ENSACAG00000010344.3	G1KJZ8	TRIB1
2		iEKPD-Anc-0012	ENSACAG00000000384.3	G1K8G5	TRIB2
3		iEKPD-Anc-0186	ENSACAG00000008188.3	H9GDK2	TRIB3