※ Trbl family introduction

    Trbl belongs to CAMK group. Three genes encoding trbl have been identified in mammals, and the related orthologus also been found in vertebrates and invertebrates. The Trbl kinases share a conserved central kinase catalytic domain flanked by not unclosely related N-terminal and C-terminal sequences. However, the kinase domains lack the key active site lysine and might be an inactive kinase. Studies show that Trbl kinases are key molecule function on controlling Mitogen-activated protein kinase cascades. For instance, human trbl-1 overexpression can modulate the activation of Ras/MEK-1/ERK pathway, and some MAPKK interacts with Trbls which results enhance of kinase activation (1).

Reference
1. Kiss-Toth, E., Bagstaff, S.M., Sung, H.Y., Jozsa, V., Dempsey, C., Caunt, J.C., Oxley, K.M., Wyllie, D.H., Polgar, T., Harte, M. et al. (2004) Human tribbles, a protein family controlling mitogen-activated protein kinase cascades. J Biol Chem, 279, 42703-42708. PMID: 15299019

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Gog-0120	ENSGGOG00000005304.3	G3QRE4	TRIB1
2		iEKPD-Gog-0460	ENSGGOG00000036149.1	A0A2I2Z7W2	TRIB2
3		iEKPD-Gog-0167	ENSGGOG00000007575.3	G3QX79	TRIB3