※ Trbl family introduction

    Trbl belongs to CAMK group. Three genes encoding trbl have been identified in mammals, and the related orthologus also been found in vertebrates and invertebrates. The Trbl kinases share a conserved central kinase catalytic domain flanked by not unclosely related N-terminal and C-terminal sequences. However, the kinase domains lack the key active site lysine and might be an inactive kinase. Studies show that Trbl kinases are key molecule function on controlling Mitogen-activated protein kinase cascades. For instance, human trbl-1 overexpression can modulate the activation of Ras/MEK-1/ERK pathway, and some MAPKK interacts with Trbls which results enhance of kinase activation (1).

Reference
1. Kiss-Toth, E., Bagstaff, S.M., Sung, H.Y., Jozsa, V., Dempsey, C., Caunt, J.C., Oxley, K.M., Wyllie, D.H., Polgar, T., Harte, M. et al. (2004) Human tribbles, a protein family controlling mitogen-activated protein kinase cascades. J Biol Chem, 279, 42703-42708. PMID: 15299019

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Paa-0371	ENSPANG00000022868.2	A0A096N070	TRIB1
2		iEKPD-Paa-0064	ENSPANG00000005636.2	A0A096NJ70	TRIB2
3		iEKPD-Paa-0383	ENSPANG00000023303.2	A0A2I3M9J7	TRIB3