Fusarium pseudograminearum      CDC25/CDC25


※ CDC25 family introduction

    CDC25 phosphatase contains three members in human genome, which are known as, cdc25A, cdc25B and cdc25C. CDC25 phosphatase is distantly related to other members of the PTP superfamily and rhodanese domain contribute to its catalytic activity (1). CDC25s are key regulator of cell cycle. Through dephosphorylation Thr14 and Tyr15 in cyclin-dependent kinases, CDK is activated and in turn drives the progression through the cell cycle (2).

Reference
1. Wang, W.Q., Sun, J.P. and Zhang, Z.Y. (2003) An overview of the protein tyrosine phosphatase superfamily. Curr Top Med Chem, 3, 739-748. PMID: 12678841
2. Karlsson-Rosenthal, C. and Millar, J.B. (2006) Cdc25: mechanisms of checkpoint inhibition and recovery. Trends Cell Biol, 16, 285-292. PMID: 16682204


There are 4 genes.  Reviewed (0 or Unreviewed (4

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Fup-g005
FPSE_01276
K3VS94
FPSE_01276
2
iEKPD-Fup-0155
FPSE_03144
K3VRW9
FPSE_03144
3
iEKPD-Fup-g015
FPSE_06261
K3VJY9
FPSE_06261
4
iEKPD-Fup-g010
FPSE_09180
K3VYH7
FPSE_09180