Oryza indica      CDC25/CDC25


※ CDC25 family introduction

    CDC25 phosphatase contains three members in human genome, which are known as, cdc25A, cdc25B and cdc25C. CDC25 phosphatase is distantly related to other members of the PTP superfamily and rhodanese domain contribute to its catalytic activity (1). CDC25s are key regulator of cell cycle. Through dephosphorylation Thr14 and Tyr15 in cyclin-dependent kinases, CDK is activated and in turn drives the progression through the cell cycle (2).

Reference
1. Wang, W.Q., Sun, J.P. and Zhang, Z.Y. (2003) An overview of the protein tyrosine phosphatase superfamily. Curr Top Med Chem, 3, 739-748. PMID: 12678841
2. Karlsson-Rosenthal, C. and Millar, J.B. (2006) Cdc25: mechanisms of checkpoint inhibition and recovery. Trends Cell Biol, 16, 285-292. PMID: 16682204


There are 2 genes.  Reviewed (0 or Unreviewed (2

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Ori-g024
BGIOSGA011602
B8ALE5
OsI_09668
2
iEKPD-Ori-g014
BGIOSGA033398
A2Z9X4
OsI_34537