※ CDC25 family introduction

    CDC25 phosphatase contains three members in human genome, which are known as, cdc25A, cdc25B and cdc25C. CDC25 phosphatase is distantly related to other members of the PTP superfamily and rhodanese domain contribute to its catalytic activity (1). CDC25s are key regulator of cell cycle. Through dephosphorylation Thr14 and Tyr15 in cyclin-dependent kinases, CDK is activated and in turn drives the progression through the cell cycle (2).

Reference
1. Wang, W.Q., Sun, J.P. and Zhang, Z.Y. (2003) An overview of the protein tyrosine phosphatase superfamily. Curr Top Med Chem, 3, 739-748. PMID: 12678841
2. Karlsson-Rosenthal, C. and Millar, J.B. (2006) Cdc25: mechanisms of checkpoint inhibition and recovery. Trends Cell Biol, 16, 285-292. PMID: 16682204

  Reviewed (0)  or Unreviewed (5) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Tra-g014	TRIAE_CS42_1DL_TGACv1_062787_AA0219940	A0A1D5SXA9
2		iEKPD-Tra-g047	TRIAE_CS42_4BL_TGACv1_321072_AA1054770	A0A1D5XJM3
3		iEKPD-Tra-g039	TRIAE_CS42_4DL_TGACv1_342977_AA1126640	A0A1D5XYH0
4		iEKPD-Tra-g045	TRIAE_CS42_5AL_TGACv1_377856_AA1249830	A0A1D5YQ92
5		iEKPD-Tra-g006	TRIAE_CS42_1BL_TGACv1_033455_AA0139600	A0A1D5SH58	CDC25.1-1BL