※ CK1 family introduction

    CK1 (Casein kinase I) is characterized by its Ser/Thr protein kinase catalytic activity on phoshorylation of casein in vitro in a cycle AMP-independent manner. Six isoforms and CK1-like kinase have been identified in this family. Sequence analysis shows that all members share a N-terminal conserved kinase catalytic domain and a variable C-terminal sequence. Several potential regulatory mechanisms for CK1s have been described including activation via phosphorylation of PKA, 14-3-3 binding and autoinhibition. CK1s are involved in a variety of cellular processes via phosphorylation of a large range of substrates, for instance, stabilizing AIB1 and increasing Erα transcriptional activity, facilitating CK1α/FADD/CaM complex assembly for proper cell cycle progression, reducing DNA-binding activity of Dnmt1, blocking nuclear export and so on. (1)

Reference
1. Cheong, J.K. and Virshup, D.M. (2011) Casein kinase 1: Complexity in the family. Int J Biochem Cell Biol, 43, 465-469. PMID: 21145983

  Reviewed (10)  or Unreviewed (4) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Art-0751	AT4G26100	P42158	CKL1
2		iEKPD-Art-0520	AT3G23340	Q9LW62	CKL10
3		iEKPD-Art-0693	AT4G14340	Q39050	CKL11
4		iEKPD-Art-0989	AT5G57015	Q8VYK9	CKL12
5		iEKPD-Art-0763	AT4G28880	Q93Z18	CKL3
6		iEKPD-Art-0762	AT4G28860	Q8LPI7	CKL4
7		iEKPD-Art-0759	AT4G28540	Q8LPJ1	CKL6
8		iEKPD-Art-0944	AT5G44100	Q9FFH8	CKL7
9		iEKPD-Art-0943	AT5G43320	Q9LSX4	CKL8
10		iEKPD-Art-0009	AT1G03930	Q9ZWB3	CKL9
11		iEKPD-Art-0352	AT2G25760	F4ISN5	At2g25750
12		iEKPD-Art-0451	AT3G03940	Q9SQR8	At3g03940
13		iEKPD-Art-0674	AT4G08800	F4JID0	At4g08800
14		iEKPD-Art-0871	AT5G18190	Q9FK52	MRG7.15