※ CK1 family introduction

    CK1 (Casein kinase I) is characterized by its Ser/Thr protein kinase catalytic activity on phoshorylation of casein in vitro in a cycle AMP-independent manner. Six isoforms and CK1-like kinase have been identified in this family. Sequence analysis shows that all members share a N-terminal conserved kinase catalytic domain and a variable C-terminal sequence. Several potential regulatory mechanisms for CK1s have been described including activation via phosphorylation of PKA, 14-3-3 binding and autoinhibition. CK1s are involved in a variety of cellular processes via phosphorylation of a large range of substrates, for instance, stabilizing AIB1 and increasing Erα transcriptional activity, facilitating CK1α/FADD/CaM complex assembly for proper cell cycle progression, reducing DNA-binding activity of Dnmt1, blocking nuclear export and so on. (1)

Reference
1. Cheong, J.K. and Virshup, D.M. (2011) Casein kinase 1: Complexity in the family. Int J Biochem Cell Biol, 43, 465-469. PMID: 21145983

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Lua-0003	TanjilG_00142	A0A1J7HZR2	TanjilG_00142
2		iEKPD-Lua-0020	TanjilG_02767	A0A1J7GXG9	TanjilG_02767
3		iEKPD-Lua-0024	TanjilG_03508	A0A1J7IKM9	TanjilG_03508
4		iEKPD-Lua-0081	TanjilG_06834	A0A1J7H616	TanjilG_06834
5		iEKPD-Lua-0113	TanjilG_08374	A0A1J7I376	TanjilG_08374
6		iEKPD-Lua-0125	TanjilG_09059	A0A1J7HQP9	TanjilG_09059
7		iEKPD-Lua-0319	TanjilG_16469	A0A1J7GS12	TanjilG_16469
8		iEKPD-Lua-0381	TanjilG_19907	A0A1J7GIL6	TanjilG_19907
9		iEKPD-Lua-0401	TanjilG_20969	A0A1J7HL01	TanjilG_20969
10		iEKPD-Lua-0559	TanjilG_30777	A0A1J7H517	TanjilG_30777
11		iEKPD-Lua-0572	TanjilG_32021	A0A1J7HR86	TanjilG_32021
12		iEKPD-Lua-0581	TanjilG_32408	A0A1J7FR75	TanjilG_32408