※ CK1 family introduction

    CK1 (Casein kinase I) is characterized by its Ser/Thr protein kinase catalytic activity on phoshorylation of casein in vitro in a cycle AMP-independent manner. Six isoforms and CK1-like kinase have been identified in this family. Sequence analysis shows that all members share a N-terminal conserved kinase catalytic domain and a variable C-terminal sequence. Several potential regulatory mechanisms for CK1s have been described including activation via phosphorylation of PKA, 14-3-3 binding and autoinhibition. CK1s are involved in a variety of cellular processes via phosphorylation of a large range of substrates, for instance, stabilizing AIB1 and increasing Erα transcriptional activity, facilitating CK1α/FADD/CaM complex assembly for proper cell cycle progression, reducing DNA-binding activity of Dnmt1, blocking nuclear export and so on. (1)

Reference
1. Cheong, J.K. and Virshup, D.M. (2011) Casein kinase 1: Complexity in the family. Int J Biochem Cell Biol, 43, 465-469. PMID: 21145983

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Mae-0218	MANES_03G024600	A0A251L674	MANES_03G024600
2		iEKPD-Mae-0223	MANES_03G035700	A0A2C9W6E7	MANES_03G035700
3		iEKPD-Mae-0234	MANES_03G060000	A0A251L7S7	MANES_03G060000
4		iEKPD-Mae-0283	MANES_03G163300	A0A2C9W811	MANES_03G163300
5		iEKPD-Mae-0381	MANES_04G133400	A0A251L528	MANES_04G133400
6		iEKPD-Mae-0386	MANES_04G141300	A0A2C9W2F0	MANES_04G141300
7		iEKPD-Mae-0697	MANES_08G143900	A0A2C9VIN1	MANES_08G143900
8		iEKPD-Mae-0770	MANES_09G147800	A0A2C9VD59	MANES_09G147800
9		iEKPD-Mae-0889	MANES_11G034400	A0A2C9UY01	MANES_11G034400
10		iEKPD-Mae-1009	MANES_12G034100	A0A2C9UT78	MANES_12G034100
11		iEKPD-Mae-1083	MANES_13G036000	A0A2C9UPN4	MANES_13G036000
12		iEKPD-Mae-1210	MANES_15G042000	A0A2C9UDW2	MANES_15G042000
13		iEKPD-Mae-1320	MANES_16G072400	A0A2C9U9D3	MANES_16G072400
14		iEKPD-Mae-1322	MANES_16G074100	A0A2C9U9T3	MANES_16G074100
15		iEKPD-Mae-1333	MANES_16G100200	A0A2C9UBG2	MANES_16G100200
16		iEKPD-Mae-1340	MANES_16G117000	A0A2C9UAQ9	MANES_16G117000