※ CK1 family introduction

    CK1 (Casein kinase I) is characterized by its Ser/Thr protein kinase catalytic activity on phoshorylation of casein in vitro in a cycle AMP-independent manner. Six isoforms and CK1-like kinase have been identified in this family. Sequence analysis shows that all members share a N-terminal conserved kinase catalytic domain and a variable C-terminal sequence. Several potential regulatory mechanisms for CK1s have been described including activation via phosphorylation of PKA, 14-3-3 binding and autoinhibition. CK1s are involved in a variety of cellular processes via phosphorylation of a large range of substrates, for instance, stabilizing AIB1 and increasing Erα transcriptional activity, facilitating CK1α/FADD/CaM complex assembly for proper cell cycle progression, reducing DNA-binding activity of Dnmt1, blocking nuclear export and so on. (1)

Reference
1. Cheong, J.K. and Virshup, D.M. (2011) Casein kinase 1: Complexity in the family. Int J Biochem Cell Biol, 43, 465-469. PMID: 21145983

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Nia-0241	A4A49_18431	A0A1J6IUY5	A4A49_18431
2		iEKPD-Nia-0260	A4A49_19864	A0A1J6HZ49	A4A49_19864
3		iEKPD-Nia-0389	A4A49_27536	A0A1J6KFM9	A4A49_27536
4		iEKPD-Nia-0510	A4A49_35190	A0A1J6JYG7	A4A49_35190
5		iEKPD-Nia-0632	A4A49_44373	A0A1J6JMH7	A4A49_44373
6		iEKPD-Nia-0652	A4A49_58667	A0A1J6HUI2	A4A49_58667
7		iEKPD-Nia-0661	A4A49_59926	A0A1J6IHB6	A4A49_59926
8		iEKPD-Nia-0663	A4A49_60408	A0A1J6KID6	A4A49_60408
9		iEKPD-Nia-0690	A4A49_65733	A0A1J6KP64	A4A49_65733
10		iEKPD-Nia-0513	A4A49_35412	A0A1J6IUG7	CKL6_3