※ CK1 family introduction

    CK1 (Casein kinase I) is characterized by its Ser/Thr protein kinase catalytic activity on phoshorylation of casein in vitro in a cycle AMP-independent manner. Six isoforms and CK1-like kinase have been identified in this family. Sequence analysis shows that all members share a N-terminal conserved kinase catalytic domain and a variable C-terminal sequence. Several potential regulatory mechanisms for CK1s have been described including activation via phosphorylation of PKA, 14-3-3 binding and autoinhibition. CK1s are involved in a variety of cellular processes via phosphorylation of a large range of substrates, for instance, stabilizing AIB1 and increasing Erα transcriptional activity, facilitating CK1α/FADD/CaM complex assembly for proper cell cycle progression, reducing DNA-binding activity of Dnmt1, blocking nuclear export and so on. (1)

Reference
1. Cheong, J.K. and Virshup, D.M. (2011) Casein kinase 1: Complexity in the family. Int J Biochem Cell Biol, 43, 465-469. PMID: 21145983

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Php-0165	PP1S1655_2V6
2		iEKPD-Php-0196	PP1S176_7V6
3		iEKPD-Php-0609	PP1S471_4V6
4		iEKPD-Php-0618	PP1S489_24V6
5		iEKPD-Php-g013	PP1S39_38V6
6		iEKPD-Php-0624	PP1S496_15V6	A9U473	PHYPADRAFT_101726
7		iEKPD-Php-0690	PP1S613_17V6	A9U598	PHYPADRAFT_102523
8		iEKPD-Php-0218	PP1S182_90V6	A9T8B5	PHYPADRAFT_141747
9		iEKPD-Php-0217	PP1S182_82V6	A9T8A9	PHYPADRAFT_141762
10		iEKPD-Php-0289	PP1S210_32V6	A9TDP5	PHYPADRAFT_144004
11		iEKPD-Php-0083	PP1S131_16V6	A9SX02	PHYPADRAFT_166955
12		iEKPD-Php-0709	PP1S66_174V6	A9SCV1	PHYPADRAFT_210931
13		iEKPD-Php-0303	PP1S216_7V6	A9TEV1	PHYPADRAFT_60088
14		iEKPD-Php-0278	PP1S208_44V6	A9TD76	PHYPADRAFT_91249
15		iEKPD-Php-0371	PP1S251_2V6	A9TMS2	PHYPADRAFT_94777
16		iEKPD-Php-g005	PP1S360_49V6	A9TXL5	PHYPADRAFT_98640