※ CK1 family introduction

    CK1 (Casein kinase I) is characterized by its Ser/Thr protein kinase catalytic activity on phoshorylation of casein in vitro in a cycle AMP-independent manner. Six isoforms and CK1-like kinase have been identified in this family. Sequence analysis shows that all members share a N-terminal conserved kinase catalytic domain and a variable C-terminal sequence. Several potential regulatory mechanisms for CK1s have been described including activation via phosphorylation of PKA, 14-3-3 binding and autoinhibition. CK1s are involved in a variety of cellular processes via phosphorylation of a large range of substrates, for instance, stabilizing AIB1 and increasing Erα transcriptional activity, facilitating CK1α/FADD/CaM complex assembly for proper cell cycle progression, reducing DNA-binding activity of Dnmt1, blocking nuclear export and so on. (1)

Reference
1. Cheong, J.K. and Virshup, D.M. (2011) Casein kinase 1: Complexity in the family. Int J Biochem Cell Biol, 43, 465-469. PMID: 21145983

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sei-0744	Si021938m.g	K3Z5X0	LOC101755509
2		iEKPD-Sei-0056	Si000563m.g	K3XF94	LOC101760429
3		iEKPD-Sei-0719	Si021536m.g	K3Z4R8	LOC101763770
4		iEKPD-Sei-0715	Si021518m.g	K3Z4Q0	LOC101765228
5		iEKPD-Sei-0117	Si001531m.g	K3XI09	LOC101765968
6		iEKPD-Sei-0597	Si017326m.g	K3YST1	LOC101771774
7		iEKPD-Sei-0044	Si000515m.g	K3XF48	LOC101772174
8		iEKPD-Sei-1140	Si033217m.g	K4A2W5	LOC101773166
9		iEKPD-Sei-0586	Si017146m.g	K3YSA2	LOC101773551
10		iEKPD-Sei-0370	Si010067m.g	K3Y776	LOC101778861
11		iEKPD-Sei-1195	Si034472m.g	K4A6G8	LOC101783890
12		iEKPD-Sei-0103	Si001239m.g	K3XH68	SETIT_001239mg