※ CK1 family introduction

    CK1 (Casein kinase I) is characterized by its Ser/Thr protein kinase catalytic activity on phoshorylation of casein in vitro in a cycle AMP-independent manner. Six isoforms and CK1-like kinase have been identified in this family. Sequence analysis shows that all members share a N-terminal conserved kinase catalytic domain and a variable C-terminal sequence. Several potential regulatory mechanisms for CK1s have been described including activation via phosphorylation of PKA, 14-3-3 binding and autoinhibition. CK1s are involved in a variety of cellular processes via phosphorylation of a large range of substrates, for instance, stabilizing AIB1 and increasing Erα transcriptional activity, facilitating CK1α/FADD/CaM complex assembly for proper cell cycle progression, reducing DNA-binding activity of Dnmt1, blocking nuclear export and so on. (1)

Reference
1. Cheong, J.K. and Virshup, D.M. (2011) Casein kinase 1: Complexity in the family. Int J Biochem Cell Biol, 43, 465-469. PMID: 21145983

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sol-0796	Solyc08g066410.1	K4CLL8
2		iEKPD-Sol-0798	Solyc08g066870.2	K4CLR3
3		iEKPD-Sol-0914	Solyc09g090230.1	K4CW49
4		iEKPD-Sol-0915	Solyc09g090240.1	K4CW50
5		iEKPD-Sol-1081	Solyc12g007280.1	K4DBR5
6		iEKPD-Sol-1144	Solyc12g095830.1	K4DH56
7		iEKPD-Sol-1062	Solyc11g070170.1	K4DAH3	101245026
8		iEKPD-Sol-0614	Solyc06g053560.2	K4C643	101248583
9		iEKPD-Sol-0916	Solyc09g090250.2	K4CW51	101255137
10		iEKPD-Sol-0542	Solyc05g016410.2	K4BZ03	101258260
11		iEKPD-Sol-0664	Solyc06g083830.2	K4CAN8	101262628
12		iEKPD-Sol-0620	Solyc06g062790.2	K4C710	101263221
13		iEKPD-Sol-0695	Solyc07g040720.2	K4CDU9	101265454
14		iEKPD-Sol-0590	Solyc06g008320.2	K4C3L2	101267121
15		iEKPD-Sol-1160	Solyc12g100310.1	K4DI52	101267788
16		iEKPD-Sol-0988	Solyc10g080700.1	K4D2W0	101268442