※ CK1 family introduction

    CK1 (Casein kinase I) is characterized by its Ser/Thr protein kinase catalytic activity on phoshorylation of casein in vitro in a cycle AMP-independent manner. Six isoforms and CK1-like kinase have been identified in this family. Sequence analysis shows that all members share a N-terminal conserved kinase catalytic domain and a variable C-terminal sequence. Several potential regulatory mechanisms for CK1s have been described including activation via phosphorylation of PKA, 14-3-3 binding and autoinhibition. CK1s are involved in a variety of cellular processes via phosphorylation of a large range of substrates, for instance, stabilizing AIB1 and increasing Erα transcriptional activity, facilitating CK1α/FADD/CaM complex assembly for proper cell cycle progression, reducing DNA-binding activity of Dnmt1, blocking nuclear export and so on. (1)

Reference
1. Cheong, J.K. and Virshup, D.M. (2011) Casein kinase 1: Complexity in the family. Int J Biochem Cell Biol, 43, 465-469. PMID: 21145983

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sob-0016	SORBI_3001G060100	C5WY18	SORBI_3001G060100
2		iEKPD-Sob-0216	SORBI_3002G047700	A0A1B6Q9B4	SORBI_3002G047700
3		iEKPD-Sob-0385	SORBI_3003G029700	C5XLU6	SORBI_3003G029700
4		iEKPD-Sob-0503	SORBI_3003G273600	C5XHN8	SORBI_3003G273600
5		iEKPD-Sob-0518	SORBI_3003G311900	A0A1W0VZQ9	SORBI_3003G311900
6		iEKPD-Sob-0617	SORBI_3004G127400	A0A194YP95	SORBI_3004G127400
7		iEKPD-Sob-0643	SORBI_3004G219000	C5XXS5	SORBI_3004G219000
8		iEKPD-Sob-0685	SORBI_3004G339200	A0A194YT20	SORBI_3004G339200
9		iEKPD-Sob-0836	SORBI_3006G146800	A0A1B6PM22	SORBI_3006G146800
10		iEKPD-Sob-1029	SORBI_3008G146100	A0A1Z5R6U6	SORBI_3008G146100
11		iEKPD-Sob-1088	SORBI_3009G074400	C5YUK9	SORBI_3009G074400
12		iEKPD-Sob-1167	SORBI_3009G257200	C5YX16	SORBI_3009G257200