※ CK1 family introduction

    CK1 (Casein kinase I) is characterized by its Ser/Thr protein kinase catalytic activity on phoshorylation of casein in vitro in a cycle AMP-independent manner. Six isoforms and CK1-like kinase have been identified in this family. Sequence analysis shows that all members share a N-terminal conserved kinase catalytic domain and a variable C-terminal sequence. Several potential regulatory mechanisms for CK1s have been described including activation via phosphorylation of PKA, 14-3-3 binding and autoinhibition. CK1s are involved in a variety of cellular processes via phosphorylation of a large range of substrates, for instance, stabilizing AIB1 and increasing Erα transcriptional activity, facilitating CK1α/FADD/CaM complex assembly for proper cell cycle progression, reducing DNA-binding activity of Dnmt1, blocking nuclear export and so on. (1)

Reference
1. Cheong, J.K. and Virshup, D.M. (2011) Casein kinase 1: Complexity in the family. Int J Biochem Cell Biol, 43, 465-469. PMID: 21145983

  Reviewed (0)  or Unreviewed (5) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Tag-0005	ENSTGUG00000000243.1	H0YPQ2	CSNK1A1
2		iEKPD-Tag-0152	ENSTGUG00000004638.1	H0Z2K8	CSNK1G1
3		iEKPD-Tag-0414	ENSTGUG00000014183.1	H0ZVD2	CSNK1G2
4		iEKPD-Tag-0043	ENSTGUG00000001103.1	H0YS74	CSNK1G3
5		iEKPD-Tag-0505	ENSTGUG00000016464.1	H1A1K6	LOC100221482