※ CK1 family introduction

    CK1 (Casein kinase I) is characterized by its Ser/Thr protein kinase catalytic activity on phoshorylation of casein in vitro in a cycle AMP-independent manner. Six isoforms and CK1-like kinase have been identified in this family. Sequence analysis shows that all members share a N-terminal conserved kinase catalytic domain and a variable C-terminal sequence. Several potential regulatory mechanisms for CK1s have been described including activation via phosphorylation of PKA, 14-3-3 binding and autoinhibition. CK1s are involved in a variety of cellular processes via phosphorylation of a large range of substrates, for instance, stabilizing AIB1 and increasing Erα transcriptional activity, facilitating CK1α/FADD/CaM complex assembly for proper cell cycle progression, reducing DNA-binding activity of Dnmt1, blocking nuclear export and so on. (1)

Reference
1. Cheong, J.K. and Virshup, D.M. (2011) Casein kinase 1: Complexity in the family. Int J Biochem Cell Biol, 43, 465-469. PMID: 21145983

  Reviewed (0)  or Unreviewed (45) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Tra-0093	TRIAE_CS42_1AL_TGACv1_002322_AA0040850	A0A1D5RXE0
2		iEKPD-Tra-0112	TRIAE_CS42_1AL_TGACv1_003757_AA0051420	A0A1D5RZP5
3		iEKPD-Tra-0246	TRIAE_CS42_1BL_TGACv1_031257_AA0110480	A0A1D6REE8
4		iEKPD-Tra-0273	TRIAE_CS42_1BL_TGACv1_032220_AA0127010	A0A1D5SED1
5		iEKPD-Tra-0429	TRIAE_CS42_1DL_TGACv1_061646_AA0200860	A0A1D5ST00
6		iEKPD-Tra-0730	TRIAE_CS42_2AS_TGACv1_112535_AA0340070	W5AZP0
7		iEKPD-Tra-1374	TRIAE_CS42_2DS_TGACv1_178006_AA0589120	W5C5Z4
8		iEKPD-Tra-1443	TRIAE_CS42_3AL_TGACv1_193616_AA0615190	A0A1D5V489
9		iEKPD-Tra-1464	TRIAE_CS42_3AL_TGACv1_194155_AA0627530	A0A1D5V6T0
10		iEKPD-Tra-1476	TRIAE_CS42_3AL_TGACv1_194450_AA0633290	A0A1D5V843
11		iEKPD-Tra-1521	TRIAE_CS42_3AL_TGACv1_195530_AA0650670	A0A1D5VBX7
12		iEKPD-Tra-1575	TRIAE_CS42_3AS_TGACv1_210735_AA0678010	W5CNL8
13		iEKPD-Tra-1621	TRIAE_CS42_3AS_TGACv1_211668_AA0692770	A0A1D5VJT0
14		iEKPD-Tra-1745	TRIAE_CS42_3B_TGACv1_221262_AA0735460	A0A1D5VSX2
15		iEKPD-Tra-1762	TRIAE_CS42_3B_TGACv1_221506_AA0742300	A0A1D5VUE5
16		iEKPD-Tra-1792	TRIAE_CS42_3B_TGACv1_222054_AA0756000
17		iEKPD-Tra-1834	TRIAE_CS42_3B_TGACv1_222876_AA0772280	A0A1D5W0B4
18		iEKPD-Tra-1853	TRIAE_CS42_3B_TGACv1_223294_AA0779880	A0A1D5W1V5
19		iEKPD-Tra-1942	TRIAE_CS42_3B_TGACv1_226547_AA0817630	A0A1D5W9Q9
20		iEKPD-Tra-2036	TRIAE_CS42_3DL_TGACv1_250136_AA0862820	A0A1D5WHR3
21		iEKPD-Tra-2156	TRIAE_CS42_3DS_TGACv1_272206_AA0916810	A0A1D5WTC0
22		iEKPD-Tra-2192	TRIAE_CS42_3DS_TGACv1_273369_AA0930670	A0A1D6RG96
23		iEKPD-Tra-2832	TRIAE_CS42_5AL_TGACv1_376557_AA1238440	A0A1D5YMS8
24		iEKPD-Tra-2836	TRIAE_CS42_5AL_TGACv1_376738_AA1240480	A0A1D5YNA3
25		iEKPD-Tra-2839	TRIAE_CS42_5AL_TGACv1_377054_AA1243610	A0A1D5YP01
26		iEKPD-Tra-2863	TRIAE_CS42_5AL_TGACv1_378800_AA1254640	A0A1D5YRA0
27		iEKPD-Tra-2904	TRIAE_CS42_5AS_TGACv1_394458_AA1280480	A0A1D5YVZ1
28		iEKPD-Tra-2919	TRIAE_CS42_5BL_TGACv1_404161_AA1287570	W5FAT6
29		iEKPD-Tra-3042	TRIAE_CS42_5BL_TGACv1_405665_AA1332520	W5FAI5
30		iEKPD-Tra-3152	TRIAE_CS42_5BS_TGACv1_424586_AA1390750	A0A1D5ZHX0
31		iEKPD-Tra-3214	TRIAE_CS42_5DL_TGACv1_433388_AA1411700	A0A1D6S5S3
32		iEKPD-Tra-3261	TRIAE_CS42_5DL_TGACv1_434030_AA1427580	W5FUB1
33		iEKPD-Tra-3347	TRIAE_CS42_5DL_TGACv1_436100_AA1458020	A0A1D5ZXK7
34		iEKPD-Tra-3356	TRIAE_CS42_5DL_TGACv1_436735_AA1462980	W5FY86
35		iEKPD-Tra-3415	TRIAE_CS42_5DS_TGACv1_458000_AA1491310	W5G2J1
36		iEKPD-Tra-3444	TRIAE_CS42_6AL_TGACv1_471263_AA1505960	A0A1D6A6K8
37		iEKPD-Tra-3486	TRIAE_CS42_6AL_TGACv1_472806_AA1526210	A0A1D6AB41
38		iEKPD-Tra-3622	TRIAE_CS42_6BL_TGACv1_500051_AA1597900	A0A1D6S9K6
39		iEKPD-Tra-3690	TRIAE_CS42_6BS_TGACv1_513201_AA1634080	A0A1D6AUV8
40		iEKPD-Tra-3958	TRIAE_CS42_6DS_TGACv1_544091_AA1746410	W5H1B2
41		iEKPD-Tra-4668	TRIAE_CS42_U_TGACv1_641495_AA2096430	A0A1D6DBM9
42		iEKPD-Tra-3450	TRIAE_CS42_6AL_TGACv1_471475_AA1509430	W5G5L1	4330018 (1 of many)
43		iEKPD-Tra-3640	TRIAE_CS42_6BL_TGACv1_500807_AA1610020	W5GN57	4330018 (1 of many)
44		iEKPD-Tra-3837	TRIAE_CS42_6DL_TGACv1_526871_AA1694040	W5GU89	4330018 (1 of many)
45		iEKPD-Tra-1707	TRIAE_CS42_3B_TGACv1_220727_AA0717170	A0A077S0Y0	TRAES_3BF042300010CFD_c1