※ CLK family introduction

    CLK kinases belong to CMGC family. CLKs are evolutionarily conserved dual specific kinase, which possess ability to mediate phosphorylation on serine, threonine and tyrosine residues. Four members have been found in human genome, known as CLK1, CLK2, CLK3 and CLK4. CLKs can be found in diverse species, including yeast, fly, Arabidoposis, mouse, rat and human. CLKs play an important role in cellular processes. The work on Drosophlia CLK homologue DOA reported that low expression of DOA show the neurologic abnormalities. In addition, more studies have identified the other physiological roles of CLK family of kinases, including regulation mRNA splicing; participate in intracellular signal transduction cascades (1).

Reference
1. Moeslein, F.M., Myers, M.P. and Landreth, G.E. (1999) The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B. J Biol Chem, 274, 26697-26704. PMID: 10480872

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Amt-0313	AMTR_s00032p00233500	U5CXZ5	AMTR_s00032p00233500
2		iEKPD-Amt-0445	AMTR_s00061p00159950	U5DAB4	AMTR_s00061p00159950
3		iEKPD-Amt-0532	AMTR_s00078p00186180	W1P8A0	AMTR_s00078p00186180
4		iEKPD-Amt-0662	AMTR_s00174p00035020	U5CZB5	AMTR_s00174p00035020