※ CLK family introduction

    CLK kinases belong to CMGC family. CLKs are evolutionarily conserved dual specific kinase, which possess ability to mediate phosphorylation on serine, threonine and tyrosine residues. Four members have been found in human genome, known as CLK1, CLK2, CLK3 and CLK4. CLKs can be found in diverse species, including yeast, fly, Arabidoposis, mouse, rat and human. CLKs play an important role in cellular processes. The work on Drosophlia CLK homologue DOA reported that low expression of DOA show the neurologic abnormalities. In addition, more studies have identified the other physiological roles of CLK family of kinases, including regulation mRNA splicing; participate in intracellular signal transduction cascades (1).

Reference
1. Moeslein, F.M., Myers, M.P. and Landreth, G.E. (1999) The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B. J Biol Chem, 274, 26697-26704. PMID: 10480872

  Reviewed (1)  or Unreviewed (3) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Cae-0137	WBGene00006517	G5EDB2	madd-3
2		iEKPD-Cae-0394	WBGene00185089	C0Z1Y5	C16A11.10
3		iEKPD-Cae-0252	WBGene00013727	Q9BHM0	CELE_Y111B2A.1
4		iEKPD-Cae-0376	WBGene00022218	Q95XE7	CELE_Y73B3A.16