※ CLK family introduction

    CLK kinases belong to CMGC family. CLKs are evolutionarily conserved dual specific kinase, which possess ability to mediate phosphorylation on serine, threonine and tyrosine residues. Four members have been found in human genome, known as CLK1, CLK2, CLK3 and CLK4. CLKs can be found in diverse species, including yeast, fly, Arabidoposis, mouse, rat and human. CLKs play an important role in cellular processes. The work on Drosophlia CLK homologue DOA reported that low expression of DOA show the neurologic abnormalities. In addition, more studies have identified the other physiological roles of CLK family of kinases, including regulation mRNA splicing; participate in intracellular signal transduction cascades (1).

Reference
1. Moeslein, F.M., Myers, M.P. and Landreth, G.E. (1999) The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B. J Biol Chem, 274, 26697-26704. PMID: 10480872

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Glm-0345	GLYMA_04G0789001
2		iEKPD-Glm-0542	GLYMA_06G080600	I1K978	100782453
3		iEKPD-Glm-0584	GLYMA_06G175900	I1KC99	100791858
4		iEKPD-Glm-0441	GLYMA_05G042700	I1K060	100804022
5		iEKPD-Glm-1966	GLYMA_17G125500	I1MUK0	100804452
6		iEKPD-Glm-0291	GLYMA_03G173600	I1JPE8	100808061
7		iEKPD-Glm-0392	GLYMA_04G189600	I1JXD2	100808961