※ CLK family introduction

    CLK kinases belong to CMGC family. CLKs are evolutionarily conserved dual specific kinase, which possess ability to mediate phosphorylation on serine, threonine and tyrosine residues. Four members have been found in human genome, known as CLK1, CLK2, CLK3 and CLK4. CLKs can be found in diverse species, including yeast, fly, Arabidoposis, mouse, rat and human. CLKs play an important role in cellular processes. The work on Drosophlia CLK homologue DOA reported that low expression of DOA show the neurologic abnormalities. In addition, more studies have identified the other physiological roles of CLK family of kinases, including regulation mRNA splicing; participate in intracellular signal transduction cascades (1).

Reference
1. Moeslein, F.M., Myers, M.P. and Landreth, G.E. (1999) The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B. J Biol Chem, 274, 26697-26704. PMID: 10480872

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Mae-0528	MANES_06G111800	A0A2C9VRZ2	MANES_06G111800
2		iEKPD-Mae-0666	MANES_08G075400	A0A2C9VEA0	MANES_08G075400
3		iEKPD-Mae-1002	MANES_12G020700	A0A2C9UT07	MANES_12G020700
4		iEKPD-Mae-1147	MANES_14G059500	A0A2C9UJ66	MANES_14G059500
5		iEKPD-Mae-1319	MANES_16G069600	A0A251IZP5	MANES_16G069600