※ CLK family introduction

    CLK kinases belong to CMGC family. CLKs are evolutionarily conserved dual specific kinase, which possess ability to mediate phosphorylation on serine, threonine and tyrosine residues. Four members have been found in human genome, known as CLK1, CLK2, CLK3 and CLK4. CLKs can be found in diverse species, including yeast, fly, Arabidoposis, mouse, rat and human. CLKs play an important role in cellular processes. The work on Drosophlia CLK homologue DOA reported that low expression of DOA show the neurologic abnormalities. In addition, more studies have identified the other physiological roles of CLK family of kinases, including regulation mRNA splicing; participate in intracellular signal transduction cascades (1).

Reference
1. Moeslein, F.M., Myers, M.P. and Landreth, G.E. (1999) The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B. J Biol Chem, 274, 26697-26704. PMID: 10480872

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sob-0013	SORBI_3001G043300	A0A1B6QH88	SORBI_3001G043300
2		iEKPD-Sob-0238	SORBI_3002G132000	A0A1B6QAZ9	SORBI_3002G132000
3		iEKPD-Sob-0467	SORBI_3003G203400	C5XPI8	SORBI_3003G203400
4		iEKPD-Sob-0537	SORBI_3003G349300	A0A1B6Q6X7	SORBI_3003G349300
5		iEKPD-Sob-0634	SORBI_3004G202500	A0A194YQT0	SORBI_3004G202500