※ CLK family introduction

    CLK kinases belong to CMGC family. CLKs are evolutionarily conserved dual specific kinase, which possess ability to mediate phosphorylation on serine, threonine and tyrosine residues. Four members have been found in human genome, known as CLK1, CLK2, CLK3 and CLK4. CLKs can be found in diverse species, including yeast, fly, Arabidoposis, mouse, rat and human. CLKs play an important role in cellular processes. The work on Drosophlia CLK homologue DOA reported that low expression of DOA show the neurologic abnormalities. In addition, more studies have identified the other physiological roles of CLK family of kinases, including regulation mRNA splicing; participate in intracellular signal transduction cascades (1).

Reference
1. Moeslein, F.M., Myers, M.P. and Landreth, G.E. (1999) The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B. J Biol Chem, 274, 26697-26704. PMID: 10480872

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Tra-1473	TRIAE_CS42_3AL_TGACv1_194295_AA0630640	A0A1D5V7H8
2		iEKPD-Tra-2848	TRIAE_CS42_5AL_TGACv1_377477_AA1247090	A0A1D6S1R6
3		iEKPD-Tra-3067	TRIAE_CS42_5BL_TGACv1_406377_AA1344780	A0A1D5Z921
4		iEKPD-Tra-3294	TRIAE_CS42_5DL_TGACv1_434617_AA1438810	A0A1D5ZT03
5		iEKPD-Tra-3457	TRIAE_CS42_6AL_TGACv1_471614_AA1511790	A0A1D6S7H9
6		iEKPD-Tra-3467	TRIAE_CS42_6AL_TGACv1_471977_AA1516450	A0A1D6A8T6
7		iEKPD-Tra-3626	TRIAE_CS42_6BL_TGACv1_500177_AA1600590	A0A1D6ANV3
8		iEKPD-Tra-3665	TRIAE_CS42_6BL_TGACv1_502018_AA1622410	A0A1D6ATE4
9		iEKPD-Tra-3809	TRIAE_CS42_6DL_TGACv1_526485_AA1684990	A0A1D6B3T4
10		iEKPD-Tra-3874	TRIAE_CS42_6DL_TGACv1_527815_AA1708860	A0A1D6B8X2
11		iEKPD-Tra-4804	TRIAE_CS42_U_TGACv1_649836_AA2148830	A0A1D6DLP8