※ DYRK family introduction

    DYRK (Dual-specificity tyrosine-regulated kinase) belong to CMGC family. Homology within the kinase domain can further classify this family into three subfamilies: DYRK kinases, homeodomain-interacting protein kinases (HIPKs), and pre-mRNA processing protein 4 kinases (PRP4s). Ten members have been found in human genome. DYRKs are characterized as dual-specificity protein kinases for their ability to mediate the phosphorylation of serine, threonine and tyrosine residues; however, the tyrosine phosphorylation activity is restricted to autophosphorylation. DYRKs play an important role and act as pleiotropic regulators in a variety of cellular functions, including cell survival, cell differentiation, gene transcription and endocytosis. Mutation or abnormal expressions always associate with diseases. Truncation mutants of DYRK1A result in clinical phenotypes, including microcephaly, intrauterine growth retardation, and developmental delay. Overexpression of DYRK1B has been reported in solid tumors, including colon and lung cancer, pancreatic ductal adenocarcinomas, and rhabdomyosarcomas, and experimental data suggest that increased amounts of DYRK1B favor tumor development (1).

Reference
1. Aranda, S., Laguna, A. and de la Luna, S. (2011) DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional roles. FASEB J, 25, 449-462. PMID: 21048044

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Mae-0466	MANES_06G001300	A0A2C9VNY5	MANES_06G001300
2		iEKPD-Mae-0512	MANES_06G070200	A0A2C9VQ34	MANES_06G070200
3		iEKPD-Mae-0636	MANES_07G130000	A0A2C9VNG4	MANES_07G130000
4		iEKPD-Mae-0699	MANES_08G158900	A0A2C9VGP3	MANES_08G158900
5		iEKPD-Mae-0768	MANES_09G131000	A0A2C9VAC6	MANES_09G131000
6		iEKPD-Mae-0796	MANES_10G011900	A0A2C9V297	MANES_10G011900
7		iEKPD-Mae-1162	MANES_14G100300	A0A2C9UKE1	MANES_14G100300