※ DYRK family introduction

    DYRK (Dual-specificity tyrosine-regulated kinase) belong to CMGC family. Homology within the kinase domain can further classify this family into three subfamilies: DYRK kinases, homeodomain-interacting protein kinases (HIPKs), and pre-mRNA processing protein 4 kinases (PRP4s). Ten members have been found in human genome. DYRKs are characterized as dual-specificity protein kinases for their ability to mediate the phosphorylation of serine, threonine and tyrosine residues; however, the tyrosine phosphorylation activity is restricted to autophosphorylation. DYRKs play an important role and act as pleiotropic regulators in a variety of cellular functions, including cell survival, cell differentiation, gene transcription and endocytosis. Mutation or abnormal expressions always associate with diseases. Truncation mutants of DYRK1A result in clinical phenotypes, including microcephaly, intrauterine growth retardation, and developmental delay. Overexpression of DYRK1B has been reported in solid tumors, including colon and lung cancer, pancreatic ductal adenocarcinomas, and rhabdomyosarcomas, and experimental data suggest that increased amounts of DYRK1B favor tumor development (1).

Reference
1. Aranda, S., Laguna, A. and de la Luna, S. (2011) DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional roles. FASEB J, 25, 449-462. PMID: 21048044

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sem-0001	SELMODRAFT_100581	D8RSU2	SELMODRAFT_100581
2		iEKPD-Sem-0002	SELMODRAFT_100748	D8RRY9	SELMODRAFT_100748
3		iEKPD-Sem-0097	SELMODRAFT_111790	D8S984	SELMODRAFT_111790
4		iEKPD-Sem-0458	SELMODRAFT_2002	D8RK09	SELMODRAFT_2002
5		iEKPD-Sem-0459	SELMODRAFT_2003	D8R4P1	SELMODRAFT_2003
6		iEKPD-Sem-0460	SELMODRAFT_2004	D8R4N8	SELMODRAFT_2004
7		iEKPD-Sem-0686	SELMODRAFT_410118	D8RDP5	SELMODRAFT_410118
8		iEKPD-Sem-0784	SELMODRAFT_427273	D8SZ29	SELMODRAFT_427273
9		iEKPD-Sem-0814	SELMODRAFT_43152	D8SVM9	SELMODRAFT_43152
10		iEKPD-Sem-0987	SELMODRAFT_73320	D8QNG5	SELMODRAFT_73320
11		iEKPD-Sem-0998	SELMODRAFT_75107	D8QQT4	SELMODRAFT_75107
12		iEKPD-Sem-1094	SELMODRAFT_86693	D8R845	SELMODRAFT_86693
13		iEKPD-Sem-1117	SELMODRAFT_90432	D8RCX1	SELMODRAFT_90432
14		iEKPD-Sem-1140	SELMODRAFT_95819	D8RK06	SELMODRAFT_95819