※ DYRK family introduction

    DYRK (Dual-specificity tyrosine-regulated kinase) belong to CMGC family. Homology within the kinase domain can further classify this family into three subfamilies: DYRK kinases, homeodomain-interacting protein kinases (HIPKs), and pre-mRNA processing protein 4 kinases (PRP4s). Ten members have been found in human genome. DYRKs are characterized as dual-specificity protein kinases for their ability to mediate the phosphorylation of serine, threonine and tyrosine residues; however, the tyrosine phosphorylation activity is restricted to autophosphorylation. DYRKs play an important role and act as pleiotropic regulators in a variety of cellular functions, including cell survival, cell differentiation, gene transcription and endocytosis. Mutation or abnormal expressions always associate with diseases. Truncation mutants of DYRK1A result in clinical phenotypes, including microcephaly, intrauterine growth retardation, and developmental delay. Overexpression of DYRK1B has been reported in solid tumors, including colon and lung cancer, pancreatic ductal adenocarcinomas, and rhabdomyosarcomas, and experimental data suggest that increased amounts of DYRK1B favor tumor development (1).

Reference
1. Aranda, S., Laguna, A. and de la Luna, S. (2011) DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional roles. FASEB J, 25, 449-462. PMID: 21048044

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sei-1247	Si035476m.g	K4A9C0	LOC101761466
2		iEKPD-Sei-0677	Si021127m.g	K3Z3L3	LOC101762555
3		iEKPD-Sei-0696	Si021362m.g	K3Z494	LOC101763628
4		iEKPD-Sei-0041	Si000468m.g	K3XF01	LOC101764617
5		iEKPD-Sei-1155	Si033999m.g	K4A545	LOC101776185
6		iEKPD-Sei-0336	Si009383m.g	K3Y595	LOC101777787
7		iEKPD-Sei-0520	Si016239m.g	K3YPP7	LOC101780979