※ GSK family introduction

    GSK (Glycogen synthase kinase 3) belong to CMGC family. Two isoforms have been identified in human genome, known as GSK3A and GSK3B. GSKs are highly conserved and have been found in nearly all eukaryote. Sequence analysis show that two genes display 85% sequence identity, and even higher in the catalytic domain (93%). Chromosomal mapping identified the cytological location of human GSK3A as 19q13.2, whereas human GSK3B maps to 3q13.3. Northern blot analysis shows that GSKs are expressed in different mammalian tissues. GSKs play an important role in a variety of cellular signaling pathways, including cellular proliferation, migration, inflammation and immue responses, glucose regulation and apoptosis (1).

Reference
3. Ali, A., Hoeflich, K.P. and Woodgett, J.R. (2001) Glycogen synthase kinase-3: properties, functions, and regulation. Chem Rev, 101, 2527-2540. PMID: 11749387

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Amt-0046	AMTR_s00003p00196730	W1P0A5	AMTR_s00003p00196730
2		iEKPD-Amt-0182	AMTR_s00019p00105860	W1PHE8	AMTR_s00019p00105860
3		iEKPD-Amt-0493	AMTR_s00071p00186380	U5DHR5	AMTR_s00071p00186380
4		iEKPD-Amt-0575	AMTR_s00096p00102520	W1P3A3	AMTR_s00096p00102520