※ GSK family introduction

    GSK (Glycogen synthase kinase 3) belong to CMGC family. Two isoforms have been identified in human genome, known as GSK3A and GSK3B. GSKs are highly conserved and have been found in nearly all eukaryote. Sequence analysis show that two genes display 85% sequence identity, and even higher in the catalytic domain (93%). Chromosomal mapping identified the cytological location of human GSK3A as 19q13.2, whereas human GSK3B maps to 3q13.3. Northern blot analysis shows that GSKs are expressed in different mammalian tissues. GSKs play an important role in a variety of cellular signaling pathways, including cellular proliferation, migration, inflammation and immue responses, glucose regulation and apoptosis (1).

Reference
3. Ali, A., Hoeflich, K.P. and Woodgett, J.R. (2001) Glycogen synthase kinase-3: properties, functions, and regulation. Chem Rev, 101, 2527-2540. PMID: 11749387

  Reviewed (10)  or Unreviewed (0) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Art-0901	AT5G26751	P43288	ASK1
2		iEKPD-Art-0032	AT1G09840	Q39019	ASK10
3		iEKPD-Art-0636	AT3G61160	O23145	ASK2
4		iEKPD-Art-0458	AT3G05840	P43289	ASK3
5		iEKPD-Art-0177	AT1G57870	Q9FVS6	ASK4
6		iEKPD-Art-0862	AT5G14640	Q8VZD5	ASK5
7		iEKPD-Art-0376	AT2G30980	Q39010	ASK6
8		iEKPD-Art-0703	AT4G18710	Q39011	ASK7
9		iEKPD-Art-0644	AT4G00720	Q96287	ASK8
10		iEKPD-Art-0015	AT1G06390	Q39012	ASK9