※ GSK family introduction

    GSK (Glycogen synthase kinase 3) belong to CMGC family. Two isoforms have been identified in human genome, known as GSK3A and GSK3B. GSKs are highly conserved and have been found in nearly all eukaryote. Sequence analysis show that two genes display 85% sequence identity, and even higher in the catalytic domain (93%). Chromosomal mapping identified the cytological location of human GSK3A as 19q13.2, whereas human GSK3B maps to 3q13.3. Northern blot analysis shows that GSKs are expressed in different mammalian tissues. GSKs play an important role in a variety of cellular signaling pathways, including cellular proliferation, migration, inflammation and immue responses, glucose regulation and apoptosis (1).

Reference
3. Ali, A., Hoeflich, K.P. and Woodgett, J.R. (2001) Glycogen synthase kinase-3: properties, functions, and regulation. Chem Rev, 101, 2527-2540. PMID: 11749387

  Reviewed (2)  or Unreviewed (5) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Cae-0056	WBGene00001746	Q9U2Q9	gsk-3
2		iEKPD-Cae-0210	WBGene00010991	Q09595	R03D7.5
3		iEKPD-Cae-0174	WBGene00008095	Q93372	C44H4.6
4		iEKPD-Cae-0306	WBGene00017672	P91267	CELE_F21F3.2
5		iEKPD-Cae-0249	WBGene00013701	Q9XX60	CELE_Y106G6D.4
6		iEKPD-Cae-0250	WBGene00013705	G5EFV1	CELE_Y106G6E.1
7		iEKPD-Cae-0172	WBGene00007977	Q93344	gska-3