Lupinus angustifolius      CMGC/GSK


※ GSK family introduction

    GSK (Glycogen synthase kinase 3) belong to CMGC family. Two isoforms have been identified in human genome, known as GSK3A and GSK3B. GSKs are highly conserved and have been found in nearly all eukaryote. Sequence analysis show that two genes display 85% sequence identity, and even higher in the catalytic domain (93%). Chromosomal mapping identified the cytological location of human GSK3A as 19q13.2, whereas human GSK3B maps to 3q13.3. Northern blot analysis shows that GSKs are expressed in different mammalian tissues. GSKs play an important role in a variety of cellular signaling pathways, including cellular proliferation, migration, inflammation and immue responses, glucose regulation and apoptosis (1).

Reference
3. Ali, A., Hoeflich, K.P. and Woodgett, J.R. (2001) Glycogen synthase kinase-3: properties, functions, and regulation. Chem Rev, 101, 2527-2540. PMID: 11749387


There are 10 genes.  Reviewed (0 or Unreviewed (10

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Lua-0045
TanjilG_05340
A0A1J7I490
TanjilG_05340
2
iEKPD-Lua-0072
TanjilG_06550
A0A1J7GFW6
TanjilG_06550
3
iEKPD-Lua-0174
TanjilG_11420
A0A1J7IMT7
TanjilG_11420
4
iEKPD-Lua-0214
TanjilG_12729
A0A1J7FNR7
TanjilG_12729
5
iEKPD-Lua-0281
TanjilG_14792
A0A1J7HK24
TanjilG_14792
6
iEKPD-Lua-0326
TanjilG_17628
A0A1J7HK82
TanjilG_17628
7
iEKPD-Lua-0345
TanjilG_18171
A0A1J7FNT6
TanjilG_18171
8
iEKPD-Lua-0420
TanjilG_22260
A0A1J7IH18
TanjilG_22260
9
iEKPD-Lua-0473
TanjilG_24244
A0A1J7H1X4
TanjilG_24244
10
iEKPD-Lua-0491
TanjilG_25221
A0A1J7HFH1
TanjilG_25221