※ GSK family introduction

    GSK (Glycogen synthase kinase 3) belong to CMGC family. Two isoforms have been identified in human genome, known as GSK3A and GSK3B. GSKs are highly conserved and have been found in nearly all eukaryote. Sequence analysis show that two genes display 85% sequence identity, and even higher in the catalytic domain (93%). Chromosomal mapping identified the cytological location of human GSK3A as 19q13.2, whereas human GSK3B maps to 3q13.3. Northern blot analysis shows that GSKs are expressed in different mammalian tissues. GSKs play an important role in a variety of cellular signaling pathways, including cellular proliferation, migration, inflammation and immue responses, glucose regulation and apoptosis (1).

Reference
3. Ali, A., Hoeflich, K.P. and Woodgett, J.R. (2001) Glycogen synthase kinase-3: properties, functions, and regulation. Chem Rev, 101, 2527-2540. PMID: 11749387

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Nia-0418	A4A49_29179	A0A1J6L297	ASK4_1
2		iEKPD-Nia-0670	A4A49_60903	A0A1J6IIJ8	ASK5_0
3		iEKPD-Nia-0657	A4A49_59632	A0A1J6KV55	ASK7_0
4		iEKPD-Nia-0237	A4A49_18005	A0A1J6ICT0	ASK7_1
5		iEKPD-Nia-0422	A4A49_29217	A0A1J6K2W5	ASK8_1
6		iEKPD-Nia-0681	A4A49_63060	A0A1J6JLV2	ASK9
7		iEKPD-Nia-0683	A4A49_64278	A0A1J6J258	NTK-1_1