※ GSK family introduction

    GSK (Glycogen synthase kinase 3) belong to CMGC family. Two isoforms have been identified in human genome, known as GSK3A and GSK3B. GSKs are highly conserved and have been found in nearly all eukaryote. Sequence analysis show that two genes display 85% sequence identity, and even higher in the catalytic domain (93%). Chromosomal mapping identified the cytological location of human GSK3A as 19q13.2, whereas human GSK3B maps to 3q13.3. Northern blot analysis shows that GSKs are expressed in different mammalian tissues. GSKs play an important role in a variety of cellular signaling pathways, including cellular proliferation, migration, inflammation and immue responses, glucose regulation and apoptosis (1).

Reference
3. Ali, A., Hoeflich, K.P. and Woodgett, J.R. (2001) Glycogen synthase kinase-3: properties, functions, and regulation. Chem Rev, 101, 2527-2540. PMID: 11749387

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Prp-0218	PRUPE_1G580900	M5XQD5	PRUPE_1G580900
2		iEKPD-Prp-0278	PRUPE_2G157000	A0A251QGB3	PRUPE_2G157000
3		iEKPD-Prp-0350	PRUPE_3G006000	M5XME6	PRUPE_3G006000
4		iEKPD-Prp-0410	PRUPE_3G115200	M5WTU1	PRUPE_3G115200
5		iEKPD-Prp-0519	PRUPE_3G287300	M5XC46	PRUPE_3G287300
6		iEKPD-Prp-0581	PRUPE_4G064700	M5WFZ2	PRUPE_4G064700
7		iEKPD-Prp-0976	PRUPE_6G307000	M5WI63	PRUPE_6G307000