※ GSK family introduction

    GSK (Glycogen synthase kinase 3) belong to CMGC family. Two isoforms have been identified in human genome, known as GSK3A and GSK3B. GSKs are highly conserved and have been found in nearly all eukaryote. Sequence analysis show that two genes display 85% sequence identity, and even higher in the catalytic domain (93%). Chromosomal mapping identified the cytological location of human GSK3A as 19q13.2, whereas human GSK3B maps to 3q13.3. Northern blot analysis shows that GSKs are expressed in different mammalian tissues. GSKs play an important role in a variety of cellular signaling pathways, including cellular proliferation, migration, inflammation and immue responses, glucose regulation and apoptosis (1).

Reference
3. Ali, A., Hoeflich, K.P. and Woodgett, J.R. (2001) Glycogen synthase kinase-3: properties, functions, and regulation. Chem Rev, 101, 2527-2540. PMID: 11749387

  Reviewed (0)  or Unreviewed (8) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sei-0122	Si001682m.g	K3XIG0	LOC101756248
2		iEKPD-Sei-0598	Si017348m.g	K3YSV3	LOC101759495
3		iEKPD-Sei-0757	Si022194m.g	K3Z6M5	LOC101762124
4		iEKPD-Sei-0120	Si001662m.g	K3XIE1	LOC101774075
5		iEKPD-Sei-0121	Si001664m.g	K3XIE2	LOC101774078
6		iEKPD-Sei-1251	Si035612m.g	K4A9Q6	LOC101774594
7		iEKPD-Sei-1264	Si035829m.g	K4AAC2	LOC101775242
8		iEKPD-Sei-0265	Si006577m.g	K3XXB9	LOC101783517