※ GSK family introduction

    GSK (Glycogen synthase kinase 3) belong to CMGC family. Two isoforms have been identified in human genome, known as GSK3A and GSK3B. GSKs are highly conserved and have been found in nearly all eukaryote. Sequence analysis show that two genes display 85% sequence identity, and even higher in the catalytic domain (93%). Chromosomal mapping identified the cytological location of human GSK3A as 19q13.2, whereas human GSK3B maps to 3q13.3. Northern blot analysis shows that GSKs are expressed in different mammalian tissues. GSKs play an important role in a variety of cellular signaling pathways, including cellular proliferation, migration, inflammation and immue responses, glucose regulation and apoptosis (1).

Reference
3. Ali, A., Hoeflich, K.P. and Woodgett, J.R. (2001) Glycogen synthase kinase-3: properties, functions, and regulation. Chem Rev, 101, 2527-2540. PMID: 11749387

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sob-0003	SORBI_3001G018100	C5WT17	SORBI_3001G018100
2		iEKPD-Sob-0114	SORBI_3001G321900	C5WUM1	SORBI_3001G321900
3		iEKPD-Sob-0381	SORBI_3003G024800	C5XL67	SORBI_3003G024800
4		iEKPD-Sob-0434	SORBI_3003G113800	C5XFS4	SORBI_3003G113800
5		iEKPD-Sob-0443	SORBI_3003G141500	A0A1B6Q3A2	SORBI_3003G141500
6		iEKPD-Sob-0610	SORBI_3004G104900	C5XYY3	SORBI_3004G104900
7		iEKPD-Sob-1075	SORBI_3009G032300	C5YZI1	SORBI_3009G032300