Aspergillus nidulans      CMGC/MAPK


※ MAPK family introduction

    MAPK (mitogen-activated protein kinase) are serine/threonine specific protein kinases belonging to CMGC kinase group. MAPKs play an important role in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines. MAPKs are involved in regulation of a variety of cellular processes, including cell proliferation, gene expression, differentiation, mitosis, cell survival and cell apoptosis. Three subfamilys constitute MAPK family, extracellular-receptor kinases (ERK), the c-Jun N-terminal kinases/stress-activated protein kinases (JNK/SAPK) and p38 MAPKinases. MAPK signaling pathways are important in animals, fungi and plants. ERK1/2 pathway is best understood in animals, which is essential for cell proliferation and cell cycle. Fus3 pathway is also well studied in fungi, which is responsible for cell cycle and mating in responses to pheromone stimulation. MAPKs pathway in plants may response to osmotic shock, oxidative stress, cold and anti-pathogen responses (1).

Reference
1. Wikipedia Annotation:    Mitogen-activated protein kinase


There are 6 genes.  Reviewed (2 or Unreviewed (4

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Asa-0019
CADANIAG00001630
Q9P419
hog1
2
iEKPD-Asa-0064
CADANIAG00005765
Q9HG11
mpkC
3
iEKPD-Asa-0037
CADANIAG00003400
C8VFS8
ANIA_05666
4
iEKPD-Asa-0025
CADANIAG00002198
C8VSY7
ANIA_10082
5
iEKPD-Asa-0036
CADANIAG00003399
C8VFS7
ANIA_10731
6
iEKPD-Asa-0056
CADANIAG00005005
C8V7D1
mpkB