※ MAPK family introduction

    MAPK (mitogen-activated protein kinase) are serine/threonine specific protein kinases belonging to CMGC kinase group. MAPKs play an important role in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines. MAPKs are involved in regulation of a variety of cellular processes, including cell proliferation, gene expression, differentiation, mitosis, cell survival and cell apoptosis. Three subfamilys constitute MAPK family, extracellular-receptor kinases (ERK), the c-Jun N-terminal kinases/stress-activated protein kinases (JNK/SAPK) and p38 MAPKinases. MAPK signaling pathways are important in animals, fungi and plants. ERK1/2 pathway is best understood in animals, which is essential for cell proliferation and cell cycle. Fus3 pathway is also well studied in fungi, which is responsible for cell cycle and mating in responses to pheromone stimulation. MAPKs pathway in plants may response to osmotic shock, oxidative stress, cold and anti-pathogen responses (1).

Reference
1. Wikipedia Annotation:    Mitogen-activated protein kinase

  Reviewed (9)  or Unreviewed (5) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Cae-0060	WBGene00002178	Q8WQG9	jnk-1
2		iEKPD-Cae-0061	WBGene00002187	O44408	kgb-1
3		iEKPD-Cae-0086	WBGene00003048	Q9U9Y8	lit-1
4		iEKPD-Cae-0270	WBGene00015478	Q11179	mapk-15
5		iEKPD-Cae-0098	WBGene00003401	P39745	mpk-1
6		iEKPD-Cae-0116	WBGene00004055	Q17446	pmk-1
7		iEKPD-Cae-0117	WBGene00004056	Q8MXI4	pmk-2
8		iEKPD-Cae-0118	WBGene00004057	O44514	pmk-3
9		iEKPD-Cae-0129	WBGene00004859	G5EBT1	sma-5
10		iEKPD-Cae-0175	WBGene00008200	Q9U3L3	C49C3.10
11		iEKPD-Cae-0301	WBGene00017277	Q19243	CELE_F09C12.2
12		iEKPD-Cae-0241	WBGene00013091	Q9XXC0	CELE_Y51B9A.9
13		iEKPD-Cae-0062	WBGene00002188	H2KZI0	kgb-2
14		iEKPD-Cae-0099	WBGene00003402	H2KYF8	mpk-2