Danio rerio      CMGC/SRPK


※ SRPK family introduction

    SRPK (serine-arginine (SR) protein kinase) belong to CMGC family. Three members have been identified in human genome, which are known as SRPK1, SRPK2 and SRPK3. SRPKs are characterized by the ability to phosphorylate the serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. More than 100 proteins contain RS domains, indicating that SRPKs are involved in a variety of cellular functions, including regulation and function in mRNA maturation, regulation of chromatin binding to the nuclear envelope, regulation of chromatin reorganization during G2/M phase progression, regulation of cyclin transcription and involved in metabolic signaling (1).

Reference
1. Giannakouros, T., Nikolakaki, E., Mylonis, I. and Georgatsou, E. (2011) Serine-arginine protein kinases: a small protein kinase family with a large cellular presence. FEBS J, 278, 570-586. PMID: 21205200


There are 5 genes.  Reviewed (0 or Unreviewed (5

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Dar-0211
ENSDARG00000030262.9
E9QC92
si:ch211-220i18.4
2
iEKPD-Dar-0510
ENSDARG00000073997.3
A8Y5S5
srpk1a
3
iEKPD-Dar-0217
ENSDARG00000031560.7
F1REN8
srpk1b
4
iEKPD-Dar-0205
ENSDARG00000029368.8
A0A0R4IUF5
srpk2
5
iEKPD-Dar-0040
ENSDARG00000005916.10
A0A0R4INZ7
srpk3