※ CDC14 family introduction

    CDC14 phosphatase belongs to a family of highly conserved DUSP phosphatases. All CDC14 family members share a conserved N-terminal core domain, in which two subdomains contribute to critical function, one is involved in substrate specificity and another subdomain acts as the phosphatase catalytic domain. The C-terminal domain of CDC14 family is variable which might be involved in subcellular localization. Protein phosphatases of CDC14 family are key regulators in cell cycle and they are characterized by controlling exit from mitosis. CDC14 is well understood in budding yeast Saccharomyces cerevisiae and studies show that ScCDC14 plays an important role in DNA replication, mitotic exit and cytokinesis. In Saccharomyces pombe CDC14-Like phosphatase, also known as Clp1, participates in G2−M transition and cytokinesis. In mammals, human CDC14B is important in regulating centriole duplication, cell cycle progression, mitotic exit, DNA damage and DNA repair (1).

Reference
1. Mocciaro, A. and Schiebel, E. (2010) Cdc14: a highly conserved family of phosphatases with non-conserved functions? J Cell Sci, 123, 2867-2876. PMID: 20720150

  Reviewed (5)  or Unreviewed (0) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Art-d005	AT1G05000	Q9ZVN4	DSP1
2		iEKPD-Art-d006	AT2G32960	Q84MD6	DSP2
3		iEKPD-Art-d007	AT3G02800	Q681Z2	DSP3
4		iEKPD-Art-d008	AT4G03960	Q940L5	DSP4
5		iEKPD-Art-d009	AT5G16480	Q9FFD7	DSP5