※ CDC14 family introduction

    CDC14 phosphatase belongs to a family of highly conserved DUSP phosphatases. All CDC14 family members share a conserved N-terminal core domain, in which two subdomains contribute to critical function, one is involved in substrate specificity and another subdomain acts as the phosphatase catalytic domain. The C-terminal domain of CDC14 family is variable which might be involved in subcellular localization. Protein phosphatases of CDC14 family are key regulators in cell cycle and they are characterized by controlling exit from mitosis. CDC14 is well understood in budding yeast Saccharomyces cerevisiae and studies show that ScCDC14 plays an important role in DNA replication, mitotic exit and cytokinesis. In Saccharomyces pombe CDC14-Like phosphatase, also known as Clp1, participates in G2−M transition and cytokinesis. In mammals, human CDC14B is important in regulating centriole duplication, cell cycle progression, mitotic exit, DNA damage and DNA repair (1).

Reference
1. Mocciaro, A. and Schiebel, E. (2010) Cdc14: a highly conserved family of phosphatases with non-conserved functions? J Cell Sci, 123, 2867-2876. PMID: 20720150

  Reviewed (0)  or Unreviewed (7) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Chr-0591	CHLREDRAFT_112184	A8I465	CDC14
2		iEKPD-Chr-g017	CHLREDRAFT_120200	A8J868	CHLREDRAFT_120200
3		iEKPD-Chr-g026	CHLREDRAFT_145427	A8IRQ3	CHLREDRAFT_145427
4		iEKPD-Chr-g009	CHLREDRAFT_93747	A8I6I3	CHLREDRAFT_93747
5		iEKPD-Chr-0573	CHLREDRAFT_160761	A8IAA3	CHLRE_02g077650v5
6		iEKPD-Chr-g023	CHLREDRAFT_184482	A8J277	MKP6
7		iEKPD-Chr-0582	CHLREDRAFT_194946	A8JH20	PTP1