※ CDC14 family introduction

    CDC14 phosphatase belongs to a family of highly conserved DUSP phosphatases. All CDC14 family members share a conserved N-terminal core domain, in which two subdomains contribute to critical function, one is involved in substrate specificity and another subdomain acts as the phosphatase catalytic domain. The C-terminal domain of CDC14 family is variable which might be involved in subcellular localization. Protein phosphatases of CDC14 family are key regulators in cell cycle and they are characterized by controlling exit from mitosis. CDC14 is well understood in budding yeast Saccharomyces cerevisiae and studies show that ScCDC14 plays an important role in DNA replication, mitotic exit and cytokinesis. In Saccharomyces pombe CDC14-Like phosphatase, also known as Clp1, participates in G2−M transition and cytokinesis. In mammals, human CDC14B is important in regulating centriole duplication, cell cycle progression, mitotic exit, DNA damage and DNA repair (1).

Reference
1. Mocciaro, A. and Schiebel, E. (2010) Cdc14: a highly conserved family of phosphatases with non-conserved functions? J Cell Sci, 123, 2867-2876. PMID: 20720150

  Reviewed (0)  or Unreviewed (6) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Mod-0504	ENSMODG00000012388.2	F6PND0
2		iEKPD-Mod-0523	ENSMODG00000000544.3	F6XN43	AAED1
3		iEKPD-Mod-0512	ENSMODG00000003521.3	K7E0V7	CDC14A
4		iEKPD-Mod-0479	ENSMODG00000011594.3	F6UZN6	CDKN3
5		iEKPD-Mod-0494	ENSMODG00000010053.2	F6TCW6	DUSP23
6		iEKPD-Mod-0529	ENSMODG00000008716.2	F6PVD7	PTPDC1