Selaginella moellendorffii      DSP/CDC14


※ CDC14 family introduction

    CDC14 phosphatase belongs to a family of highly conserved DUSP phosphatases. All CDC14 family members share a conserved N-terminal core domain, in which two subdomains contribute to critical function, one is involved in substrate specificity and another subdomain acts as the phosphatase catalytic domain. The C-terminal domain of CDC14 family is variable which might be involved in subcellular localization. Protein phosphatases of CDC14 family are key regulators in cell cycle and they are characterized by controlling exit from mitosis. CDC14 is well understood in budding yeast Saccharomyces cerevisiae and studies show that ScCDC14 plays an important role in DNA replication, mitotic exit and cytokinesis. In Saccharomyces pombe CDC14-Like phosphatase, also known as Clp1, participates in G2−M transition and cytokinesis. In mammals, human CDC14B is important in regulating centriole duplication, cell cycle progression, mitotic exit, DNA damage and DNA repair (1).

Reference
1. Mocciaro, A. and Schiebel, E. (2010) Cdc14: a highly conserved family of phosphatases with non-conserved functions? J Cell Sci, 123, 2867-2876. PMID: 20720150


There are 8 genes.  Reviewed (0 or Unreviewed (8

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Sem-g032
SELMODRAFT_107045
D8RLF6
SELMODRAFT_107045
2
iEKPD-Sem-g052
SELMODRAFT_117440
D8SIC6
SELMODRAFT_117440
3
iEKPD-Sem-g010
SELMODRAFT_231635
D8RHE3
SELMODRAFT_231635
4
iEKPD-Sem-1201
SELMODRAFT_3248
D8STT9
SELMODRAFT_3248
5
iEKPD-Sem-g018
SELMODRAFT_444121
D8S732
SELMODRAFT_444121
6
iEKPD-Sem-g009
SELMODRAFT_447369
D8SYV9
SELMODRAFT_447369
7
iEKPD-Sem-g008
SELMODRAFT_85091
D8R3N5
SELMODRAFT_85091
8
iEKPD-Sem-1200
SELMODRAFT_91859
D8RE91
SELMODRAFT_91859