※ CDC14 family introduction

    CDC14 phosphatase belongs to a family of highly conserved DUSP phosphatases. All CDC14 family members share a conserved N-terminal core domain, in which two subdomains contribute to critical function, one is involved in substrate specificity and another subdomain acts as the phosphatase catalytic domain. The C-terminal domain of CDC14 family is variable which might be involved in subcellular localization. Protein phosphatases of CDC14 family are key regulators in cell cycle and they are characterized by controlling exit from mitosis. CDC14 is well understood in budding yeast Saccharomyces cerevisiae and studies show that ScCDC14 plays an important role in DNA replication, mitotic exit and cytokinesis. In Saccharomyces pombe CDC14-Like phosphatase, also known as Clp1, participates in G2−M transition and cytokinesis. In mammals, human CDC14B is important in regulating centriole duplication, cell cycle progression, mitotic exit, DNA damage and DNA repair (1).

Reference
1. Mocciaro, A. and Schiebel, E. (2010) Cdc14: a highly conserved family of phosphatases with non-conserved functions? J Cell Sci, 123, 2867-2876. PMID: 20720150

  Reviewed (0)  or Unreviewed (5) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Tra-g008	TRIAE_CS42_4AS_TGACv1_307981_AA1025000	A0A1D5XDS5
2		iEKPD-Tra-g013	TRIAE_CS42_6DL_TGACv1_527411_AA1703600	W5GUP5
3		iEKPD-Tra-g042	TRIAE_CS42_7AS_TGACv1_570932_AA1842570	A0A1D6BZD0
4		iEKPD-Tra-g031	TRIAE_CS42_7BS_TGACv1_591944_AA1926280	A0A1D6CEA4
5		iEKPD-Tra-g002	TRIAE_CS42_7DS_TGACv1_624388_AA2060930	A0A1D6D560