※ MKP family introduction

    MAPK phosphatase (MKP) is a large family of dual-specificity phosphatases. The family members are characterized by the C-terminal catalytic domains which share the sequence similarity with prototypic dual-specificity protein phosphatase VH-1 and the N-terminal domain contains two regions of sequence similarity to the catalytic domain of the Cdc25 phosphatase. MKP is involved in varieties of cellular processes. DUSP10/MKP-5 can negatively regulate the JNK signaling pathway and plays an important role in negatively regulating innate immune responses and proper T cell function. In addition, DUSP10/MKP-5 can regulate p38 MAPK activity. DUSP1/MKP-1 is involved in regulating metabolic by dephosphorylating its MAPK substrates. DUSP9/MKP-4 plays a critical role in placental development and function. DUSP6/MKP-3 acts as a negative feedback regulator of fibroblast growth factor signaling (1).

Reference
1. Dickinson, R.J. and Keyse, S.M. (2006) Diverse physiological functions for dual-specificity MAP kinase phosphatases. J Cell Sci, 119, 4607-4615. PMID: 17093265

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Dan-0485	ENSDNOG00000000396.2
2		iEKPD-Dan-0487	ENSDNOG00000000589.1
3		iEKPD-Dan-0494	ENSDNOG00000001858.2
4		iEKPD-Dan-0499	ENSDNOG00000003371.2
5		iEKPD-Dan-0511	ENSDNOG00000008214.2
6		iEKPD-Dan-0516	ENSDNOG00000010346.3
7		iEKPD-Dan-0525	ENSDNOG00000011901.2
8		iEKPD-Dan-0539	ENSDNOG00000014668.3
9		iEKPD-Dan-0546	ENSDNOG00000016631.3
10		iEKPD-Dan-0550	ENSDNOG00000018079.2
11		iEKPD-Dan-0553	ENSDNOG00000019035.2
12		iEKPD-Dan-0567	ENSDNOG00000031488.1
13		iEKPD-Dan-0601	ENSDNOG00000041204.1
14		iEKPD-Dan-0626	ENSDNOG00000046869.1
15		iEKPD-Dan-0633	ENSDNOG00000049169.1