※ MKP family introduction

    MAPK phosphatase (MKP) is a large family of dual-specificity phosphatases. The family members are characterized by the C-terminal catalytic domains which share the sequence similarity with prototypic dual-specificity protein phosphatase VH-1 and the N-terminal domain contains two regions of sequence similarity to the catalytic domain of the Cdc25 phosphatase. MKP is involved in varieties of cellular processes. DUSP10/MKP-5 can negatively regulate the JNK signaling pathway and plays an important role in negatively regulating innate immune responses and proper T cell function. In addition, DUSP10/MKP-5 can regulate p38 MAPK activity. DUSP1/MKP-1 is involved in regulating metabolic by dephosphorylating its MAPK substrates. DUSP9/MKP-4 plays a critical role in placental development and function. DUSP6/MKP-3 acts as a negative feedback regulator of fibroblast growth factor signaling (1).

Reference
1. Dickinson, R.J. and Keyse, S.M. (2006) Diverse physiological functions for dual-specificity MAP kinase phosphatases. J Cell Sci, 119, 4607-4615. PMID: 17093265

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Glm-2487	GLYMA_18G013200
2		iEKPD-Glm-2466	GLYMA_17G016700	C6SYZ7	100306342
3		iEKPD-Glm-2498	GLYMA_11G243900	I1LNF8	100775448
4		iEKPD-Glm-2496	GLYMA_18G286300	I1N525	100777406
5		iEKPD-Glm-2504	GLYMA_02G095100	K7K7C7	100790177
6		iEKPD-Glm-2401	GLYMA_05G227000	I1K5Y8	100791658
7		iEKPD-Glm-2444	GLYMA_05G201200	K7KS75	100791993
8		iEKPD-Glm-2436	GLYMA_08G008600	I1KP33	100799468
9		iEKPD-Glm-2486	GLYMA_08G131200	I1KSW7	100802311
10		iEKPD-Glm-2473	GLYMA_14G051200	I1M7K1	100806021
11		iEKPD-Glm-2465	GLYMA_07G257400	I1KN93	100806191
12		iEKPD-Glm-2472	GLYMA_02G266300	I1JIH0	100808721
13		iEKPD-Glm-2443	GLYMA_04G200300	I1JXP8	102661225
14		iEKPD-Glm-2490	GLYMA_05G174000	K7KQT9	GLYMA_05G174000
15		iEKPD-Glm-2442	GLYMA_06G165300	K7KVG7	GLYMA_06G165300