※ MKP family introduction

    MAPK phosphatase (MKP) is a large family of dual-specificity phosphatases. The family members are characterized by the C-terminal catalytic domains which share the sequence similarity with prototypic dual-specificity protein phosphatase VH-1 and the N-terminal domain contains two regions of sequence similarity to the catalytic domain of the Cdc25 phosphatase. MKP is involved in varieties of cellular processes. DUSP10/MKP-5 can negatively regulate the JNK signaling pathway and plays an important role in negatively regulating innate immune responses and proper T cell function. In addition, DUSP10/MKP-5 can regulate p38 MAPK activity. DUSP1/MKP-1 is involved in regulating metabolic by dephosphorylating its MAPK substrates. DUSP9/MKP-4 plays a critical role in placental development and function. DUSP6/MKP-3 acts as a negative feedback regulator of fibroblast growth factor signaling (1).

Reference
1. Dickinson, R.J. and Keyse, S.M. (2006) Diverse physiological functions for dual-specificity MAP kinase phosphatases. J Cell Sci, 119, 4607-4615. PMID: 17093265

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Lua-0599	TanjilG_06477	A0A1J7IRL1	TanjilG_06477
2		iEKPD-Lua-0616	TanjilG_11929	A0A1J7H364	TanjilG_11929
3		iEKPD-Lua-0619	TanjilG_12074	A0A1J7HY51	TanjilG_12074
4		iEKPD-Lua-0647	TanjilG_19872	A0A1J7HYG0	TanjilG_19872
5		iEKPD-Lua-0650	TanjilG_20287	A0A1J7HRF0	TanjilG_20287
6		iEKPD-Lua-0651	TanjilG_20314	A0A1J7IUU8	TanjilG_20314
7		iEKPD-Lua-0661	TanjilG_25004	A0A1J7GGM8	TanjilG_25004