※ MKP family introduction

    MAPK phosphatase (MKP) is a large family of dual-specificity phosphatases. The family members are characterized by the C-terminal catalytic domains which share the sequence similarity with prototypic dual-specificity protein phosphatase VH-1 and the N-terminal domain contains two regions of sequence similarity to the catalytic domain of the Cdc25 phosphatase. MKP is involved in varieties of cellular processes. DUSP10/MKP-5 can negatively regulate the JNK signaling pathway and plays an important role in negatively regulating innate immune responses and proper T cell function. In addition, DUSP10/MKP-5 can regulate p38 MAPK activity. DUSP1/MKP-1 is involved in regulating metabolic by dephosphorylating its MAPK substrates. DUSP9/MKP-4 plays a critical role in placental development and function. DUSP6/MKP-3 acts as a negative feedback regulator of fibroblast growth factor signaling (1).

Reference
1. Dickinson, R.J. and Keyse, S.M. (2006) Diverse physiological functions for dual-specificity MAP kinase phosphatases. J Cell Sci, 119, 4607-4615. PMID: 17093265

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Mae-1566	MANES_03G184200	A0A2C9W8R3	MANES_03G184200
2		iEKPD-Mae-1588	MANES_06G125700	A0A2C9VSC9	MANES_06G125700
3		iEKPD-Mae-1596	MANES_07G110400	A0A2C9VKH6	MANES_07G110400
4		iEKPD-Mae-1631	MANES_10G037800	A0A2C9V4L2	MANES_10G037800
5		iEKPD-Mae-1648	MANES_12G020900	A0A2C9UU94	MANES_12G020900
6		iEKPD-Mae-1650	MANES_12G056500	A0A2C9UTW3	MANES_12G056500
7		iEKPD-Mae-1655	MANES_13G064900	A0A2C9UP75	MANES_13G064900
8		iEKPD-Mae-1671	MANES_15G023800	A0A2C9UCD9	MANES_15G023800
9		iEKPD-Mae-1688	MANES_16G108300	A0A2C9UBN0	MANES_16G108300