※ MKP family introduction

    MAPK phosphatase (MKP) is a large family of dual-specificity phosphatases. The family members are characterized by the C-terminal catalytic domains which share the sequence similarity with prototypic dual-specificity protein phosphatase VH-1 and the N-terminal domain contains two regions of sequence similarity to the catalytic domain of the Cdc25 phosphatase. MKP is involved in varieties of cellular processes. DUSP10/MKP-5 can negatively regulate the JNK signaling pathway and plays an important role in negatively regulating innate immune responses and proper T cell function. In addition, DUSP10/MKP-5 can regulate p38 MAPK activity. DUSP1/MKP-1 is involved in regulating metabolic by dephosphorylating its MAPK substrates. DUSP9/MKP-4 plays a critical role in placental development and function. DUSP6/MKP-3 acts as a negative feedback regulator of fibroblast growth factor signaling (1).

Reference
1. Dickinson, R.J. and Keyse, S.M. (2006) Diverse physiological functions for dual-specificity MAP kinase phosphatases. J Cell Sci, 119, 4607-4615. PMID: 17093265

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Mim-0505	ENSMICG00000002706.3
2		iEKPD-Mim-0509	ENSMICG00000003929.3
3		iEKPD-Mim-0520	ENSMICG00000005109.3
4		iEKPD-Mim-0525	ENSMICG00000006088.3
5		iEKPD-Mim-0530	ENSMICG00000006787.3
6		iEKPD-Mim-0553	ENSMICG00000011713.3
7		iEKPD-Mim-0581	ENSMICG00000027820.2
8		iEKPD-Mim-0586	ENSMICG00000028755.2
9		iEKPD-Mim-0587	ENSMICG00000029118.2
10		iEKPD-Mim-0590	ENSMICG00000029759.2
11		iEKPD-Mim-0594	ENSMICG00000031119.2
12		iEKPD-Mim-0604	ENSMICG00000034888.2
13		iEKPD-Mim-0606	ENSMICG00000035927.2
14		iEKPD-Mim-0609	ENSMICG00000036932.2
15		iEKPD-Mim-0614	ENSMICG00000037572.2
16		iEKPD-Mim-0615	ENSMICG00000037736.2
17		iEKPD-Mim-0616	ENSMICG00000037859.2
18		iEKPD-Mim-0620	ENSMICG00000042532.1
19		iEKPD-Mim-0621	ENSMICG00000042872.1
20		iEKPD-Mim-0622	ENSMICG00000044469.1