※ MKP family introduction

    MAPK phosphatase (MKP) is a large family of dual-specificity phosphatases. The family members are characterized by the C-terminal catalytic domains which share the sequence similarity with prototypic dual-specificity protein phosphatase VH-1 and the N-terminal domain contains two regions of sequence similarity to the catalytic domain of the Cdc25 phosphatase. MKP is involved in varieties of cellular processes. DUSP10/MKP-5 can negatively regulate the JNK signaling pathway and plays an important role in negatively regulating innate immune responses and proper T cell function. In addition, DUSP10/MKP-5 can regulate p38 MAPK activity. DUSP1/MKP-1 is involved in regulating metabolic by dephosphorylating its MAPK substrates. DUSP9/MKP-4 plays a critical role in placental development and function. DUSP6/MKP-3 acts as a negative feedback regulator of fibroblast growth factor signaling (1).

Reference
1. Dickinson, R.J. and Keyse, S.M. (2006) Diverse physiological functions for dual-specificity MAP kinase phosphatases. J Cell Sci, 119, 4607-4615. PMID: 17093265

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Ora-0549	ENSOANG00000000734.2	F6YLQ5
2		iEKPD-Ora-0501	ENSOANG00000008570.2	F6PIH9
3		iEKPD-Ora-0520	ENSOANG00000010174.4	F7E171
4		iEKPD-Ora-0540	ENSOANG00000014252.2	F6VLQ3
5		iEKPD-Ora-0535	ENSOANG00000030978.1	K7EBR9
6		iEKPD-Ora-0539	ENSOANG00000031296.1	F6PII3
7		iEKPD-Ora-0532	ENSOANG00000014560.2	F7CQH8	DUSP1
8		iEKPD-Ora-0545	ENSOANG00000001437.2	F7GDU1	DUSP10
9		iEKPD-Ora-0513	ENSOANG00000007135.1	F6PUA3	DUSP14
10		iEKPD-Ora-0516	ENSOANG00000006826.2	F6VGE2	DUSP28
11		iEKPD-Ora-0543	ENSOANG00000001597.2	F7F0Y9	DUSP5
12		iEKPD-Ora-0534	ENSOANG00000006638.2	F7C5J3	DUSP6
13		iEKPD-Ora-0541	ENSOANG00000014855.2	F7B750	DUSP7
14		iEKPD-Ora-0546	ENSOANG00000005316.2	F7C4T4	DUSP9
15		iEKPD-Ora-0536	ENSOANG00000003742.2	F7D3T1	LOC100076782
16		iEKPD-Ora-0537	ENSOANG00000001348.2	F7F2Q8	STYX