※ MKP family introduction

    MAPK phosphatase (MKP) is a large family of dual-specificity phosphatases. The family members are characterized by the C-terminal catalytic domains which share the sequence similarity with prototypic dual-specificity protein phosphatase VH-1 and the N-terminal domain contains two regions of sequence similarity to the catalytic domain of the Cdc25 phosphatase. MKP is involved in varieties of cellular processes. DUSP10/MKP-5 can negatively regulate the JNK signaling pathway and plays an important role in negatively regulating innate immune responses and proper T cell function. In addition, DUSP10/MKP-5 can regulate p38 MAPK activity. DUSP1/MKP-1 is involved in regulating metabolic by dephosphorylating its MAPK substrates. DUSP9/MKP-4 plays a critical role in placental development and function. DUSP6/MKP-3 acts as a negative feedback regulator of fibroblast growth factor signaling (1).

Reference
1. Dickinson, R.J. and Keyse, S.M. (2006) Diverse physiological functions for dual-specificity MAP kinase phosphatases. J Cell Sci, 119, 4607-4615. PMID: 17093265

  Reviewed (0)  or Unreviewed (8) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Put-0132	PTTG_01592
2		iEKPD-Put-0141	PTTG_03167
3		iEKPD-Put-0131	PTTG_01350	A0A180GAE1	PTTG_01350
4		iEKPD-Put-0154	PTTG_06841	A0A180H2K1	PTTG_06841
5		iEKPD-Put-0156	PTTG_07313	A0A180H0L1	PTTG_07313
6		iEKPD-Put-0161	PTTG_09707	A0A180GAL5	PTTG_09707
7		iEKPD-Put-0130	PTTG_01278	A0A180G0D5	PTTG_10854
8		iEKPD-Put-0128	PTTG_00845	A0A180GM32	PTTG_27306