※ MKP family introduction

    MAPK phosphatase (MKP) is a large family of dual-specificity phosphatases. The family members are characterized by the C-terminal catalytic domains which share the sequence similarity with prototypic dual-specificity protein phosphatase VH-1 and the N-terminal domain contains two regions of sequence similarity to the catalytic domain of the Cdc25 phosphatase. MKP is involved in varieties of cellular processes. DUSP10/MKP-5 can negatively regulate the JNK signaling pathway and plays an important role in negatively regulating innate immune responses and proper T cell function. In addition, DUSP10/MKP-5 can regulate p38 MAPK activity. DUSP1/MKP-1 is involved in regulating metabolic by dephosphorylating its MAPK substrates. DUSP9/MKP-4 plays a critical role in placental development and function. DUSP6/MKP-3 acts as a negative feedback regulator of fibroblast growth factor signaling (1).

Reference
1. Dickinson, R.J. and Keyse, S.M. (2006) Diverse physiological functions for dual-specificity MAP kinase phosphatases. J Cell Sci, 119, 4607-4615. PMID: 17093265

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sem-1285	SELMODRAFT_113946	D8SCL1	SELMODRAFT_113946
2		iEKPD-Sem-1291	SELMODRAFT_116653	D8SGT4	SELMODRAFT_116653
3		iEKPD-Sem-1314	SELMODRAFT_121680	D8SPG3	SELMODRAFT_121680
4		iEKPD-Sem-1277	SELMODRAFT_128331	D8S7F7	SELMODRAFT_128331
5		iEKPD-Sem-1175	SELMODRAFT_138678	D8TFX3	SELMODRAFT_138678
6		iEKPD-Sem-1176	SELMODRAFT_151004	D8RY70	SELMODRAFT_151004
7		iEKPD-Sem-1202	SELMODRAFT_180850	D8SLN6	SELMODRAFT_180850
8		iEKPD-Sem-1294	SELMODRAFT_25589	D8RC28	SELMODRAFT_25589
9		iEKPD-Sem-1280	SELMODRAFT_27558	D8R916	SELMODRAFT_27558
10		iEKPD-Sem-1275	SELMODRAFT_27710	D8T0S8	SELMODRAFT_27710
11		iEKPD-Sem-1274	SELMODRAFT_27712	D8QQ09	SELMODRAFT_27712
12		iEKPD-Sem-1287	SELMODRAFT_27738	D8SZJ9	SELMODRAFT_27738
13		iEKPD-Sem-1282	SELMODRAFT_27741	D8T3H0	SELMODRAFT_27741
14		iEKPD-Sem-1297	SELMODRAFT_27743	D8RQX2	SELMODRAFT_27743
15		iEKPD-Sem-1289	SELMODRAFT_406660	D8R123	SELMODRAFT_406660
16		iEKPD-Sem-1290	SELMODRAFT_408631	D8R9F9	SELMODRAFT_408631
17		iEKPD-Sem-1296	SELMODRAFT_412678	D8RL46	SELMODRAFT_412678
18		iEKPD-Sem-1292	SELMODRAFT_416191	D8RYD2	SELMODRAFT_416191
19		iEKPD-Sem-1293	SELMODRAFT_417062	D8S188	SELMODRAFT_417062
20		iEKPD-Sem-1299	SELMODRAFT_417243	D8S2K7	SELMODRAFT_417243
21		iEKPD-Sem-1284	SELMODRAFT_421263	D8SEI2	SELMODRAFT_421263
22		iEKPD-Sem-1288	SELMODRAFT_423066	D8SKG5	SELMODRAFT_423066
23		iEKPD-Sem-1278	SELMODRAFT_68807	D8QYM1	SELMODRAFT_68807
24		iEKPD-Sem-1185	SELMODRAFT_89622	D8RBG4	SELMODRAFT_89622
25		iEKPD-Sem-1286	SELMODRAFT_91575	D8REX4	SELMODRAFT_91575
26		iEKPD-Sem-1324	SELMODRAFT_92881	D8RG08	SELMODRAFT_92881
27		iEKPD-Sem-1203	SELMODRAFT_97017	D8RMK4	SELMODRAFT_97017